Satire (طنز) is the use of humor, irony, or exaggeration to criticize people's vices. 'Sarcasm' (طعنہ زنی) (using irony to mock) is a key tool of satire.

To be satiated (سیر) means to be fully 'satisfied' (مطمئن) in one's appetite or desire. 'Craving' (شدید خواہش) is the antonym.

Sapient (عقلمند) is a formal word for 'wise' (دانشمند) or attempting to appear wise. (It is the root of 'Homo sapiens').

Sang-froid (اطمینان) is a French phrase meaning 'cold blood'. It signifies composure or 'calmness in an emergency' (ہنگامی صورتحال میں پرسکون رہنا).

Salvation (نجات) is deliverance from sin, ruin, or loss. 'Reclamation' (بازیافت) (recovering possession) is the closest synonym, implying saving something that was lost. 'Loss' (نقصان) is the antonym.

Salutary (فائدہ مند) means producing 'good' (اچھا) effects; beneficial, especially in reference to something unwelcome (e.g., a salutary lesson). 'Having a bad effect' (برا اثر) is an antonym.

A sally (دھاوا) is a 'sudden attack' (اچانک حملہ) or rush forward from a defensive position (a 'sortie').

Sagacity (دانائی) is the quality of having keen mental discernment and good judgment; wisdom. 'Prudence' (احتیاط) or 'wisdom' is the best synonym. 'Foolishness' (بے وقوفی) is the antonym.

A sabbatical (سباتی) is a period of paid 'leave of absence' (رخصت) for a professor, typically for study or travel.

A rut (ملاپ کا موسم) is the annual 'mating season' (جنسی ملاپ کا زمانہ) for certain animals (like deer). It also means a fixed, dull routine.